NASA is developing systems for manned deep space missions, including ways to protect the physiological and psychological well-being of the crew for long periods. Long duration spaceflight adversely affects the eyes of astronauts a condition known as Spaceflight-Associated Neuro-ocular Syndrome (SANS). The damage looks as though it cold be a result of excess intra cranial fluid pressure (ICP) due to body fluid shifts in the absence of gravity. NASA’s Fluid Shift Project has employed Otoacoustic Emissions on board the International Space Station as one of several techniques capable for detecting changed ICP. P.I’s and coordinators for OAE measurements were Drs Richard Danielson and Douglas Ebert. NASA grants NNX13AK30G, NNX13AJ12G, and the Human Health and Performance Contract (HHPC).